Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth.

@article{Wang1993IdentificationOS,
  title={Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth.},
  author={Hong Gang Wang and Y Rikitake and Malcolm C Carter and Peter Yaciuk and Sir E. P. Abraham and Brad Zerler and Erica Mor{\'a}n},
  journal={Journal of virology},
  year={1993},
  volume={67 1},
  pages={476-88}
}
Adenovirus early region 1A (E1A) oncogene-encoded sequences essential for transformation- and cell growth-regulating activities are localized at the N terminus and in regions of highly conserved amino acid sequence designated conserved regions 1 and 2. These regions interact to form the binding sites for two classes of cellular proteins: those, such as the retinoblastoma gene product, whose association with the E1A products is specifically dependent on region 2, and another class which so far… CONTINUE READING
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