Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation.

@article{Piccio2008IdentificationOS,
  title={Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation.},
  author={Laura Piccio and Cecilia Buonsanti and Marina Cella and Ilaria Tassi and Robert E. Schmidt and Chiara Fenoglio and John Robert Rinker and Robert T. Naismith and Paola Panina-Bordignon and Nadia Passini and Daniela Galimberti and Elio Scarpini and Marco Colonna and Anne H. Cross},
  journal={Brain : a journal of neurology},
  year={2008},
  volume={131 Pt 11},
  pages={3081-91}
}
Triggering receptor expressed on myeloid cells 2 (TREM-2) is a membrane-bound receptor expressed by microglia and macrophages. Engagement of TREM-2 on these cells has been reported to reduce inflammatory responses and, in microglial cells, to promote phagocytosis. TREM-2 function is critical within the CNS, as its genetic deficiency in humans causes neurodegeneration with myelin and axonal loss. Blockade of TREM-2 worsened the mouse model for multiple sclerosis. In the present study, a soluble… CONTINUE READING
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