Identification of small molecules that support human leukemia stem cell activity ex vivo

  title={Identification of small molecules that support human leukemia stem cell activity ex vivo},
  author={Caroline Pabst and Jana Krosl and Iman Fares and Genevi{\`e}ve Boucher and R{\'e}jean Ruel and Anne Marinier and S{\'e}bastien Lemieux and J. -L. Hebert and Guy Sauvageau},
  journal={Nature Methods},
Leukemic stem cells (LSCs) are considered a major cause of relapse in acute myeloid leukemia (AML). Defining pathways that control LSC self-renewal is crucial for a better understanding of underlying mechanisms and for the development of targeted therapies. However, currently available culture conditions do not prevent spontaneous differentiation of LSCs, which greatly limits the feasibility of cell-based assays. To overcome these constraints we conducted a high-throughput chemical screen and… CONTINUE READING
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