Identification of small molecules that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven transformation.

Abstract

The Myc transcription factor plays a central role in the regulation of cell cycle progression, apoptosis, angiogenesis, and cellular transformation. Myc is a potent oncoprotein that is deregulated in a wide variety of human tumors and is therefore an attractive target for novel cancer therapies. Using a cellular screening approach, we have identified low… (More)

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