Identification of small-molecule inhibitors of the Abeta-ABAD interaction.

  title={Identification of small-molecule inhibitors of the Abeta-ABAD interaction.},
  author={Yuli Xie and Shixian Deng and Zhenzhang Chen and Shidu Yan and Donald W. Landry},
  journal={Bioorganic & medicinal chemistry letters},
  volume={16 17},
The interaction of amyloid beta peptide (Abeta) and Abeta-binding alcohol dehydrogenase (ABAD) was recently implicated in the pathogenesis of Alzheimer's disease (AD). Using an ELISA-based screening assay, we identified frentizole, an FDA-approved immunosuppressive drug, as a novel inhibitor of the Abeta-ABAD interaction. Analysis of the frentizole structure-activity relationship led to identification of a novel benzothiazole urea with a 30-fold improvement in potency. 

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…