Identification of small molecule inhibitors of anthrax lethal factor

@article{Panchal2004IdentificationOS,
  title={Identification of small molecule inhibitors of anthrax lethal factor},
  author={Rekha Panchal and Ann R. Hermone and Tam Luong Nguyen and Thiang Yian Wong and Robert Schwarzenbacher and J. W. Schmidt and Douglas J. Lane and Connor F McGrath and Benjamin E. Turk and James C. Burnett and M Javad Aman and Stephen Little and Edward A. Sausville and Daniel W. Zaharevitz and Lewis C. Cantley and Robert C. Liddington and Rick Gussio and Sina Bavari},
  journal={Nature Structural &Molecular Biology},
  year={2004},
  volume={11},
  pages={67-72}
}
The virulent spore-forming bacterium Bacillus anthracis secretes anthrax toxin composed of protective antigen (PA), lethal factor (LF) and edema factor (EF). LF is a Zn-dependent metalloprotease that inactivates key signaling molecules, such as mitogen-activated protein kinase kinases (MAPKK), to ultimately cause cell death. We report here the identification of small molecule (nonpeptidic) inhibitors of LF. Using a two-stage screening assay, we determined the LF inhibitory properties of 19… CONTINUE READING

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Crystal structure of the anthrax lethal factor

A. D. Pannifer
Nature • 2001

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