Identification of small-molecule antagonists that inhibit an activator: coactivator interaction.

@article{Best2004IdentificationOS,
  title={Identification of small-molecule antagonists that inhibit an activator: coactivator interaction.},
  author={Jennifer L Best and Carlos A Amezcua and Bernhard Mayr and Lawrence M Flechner and Christopher M. Murawsky and Beverly M. Emerson and Tsaffrir Zor and Kevin H Gardner and Marc R. Montminy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 51},
  pages={17622-7}
}
Phosphorylation of the cAMP response element binding protein (CREB) at Ser-133 in response to hormonal stimuli triggers cellular gene expression via the recruitment of the histone acetylase coactivator paralogs CREB binding protein (CBP) and p300 to the promoter. The NMR structure of the CREB:CBP complex, using relevant interaction domains called KID and… CONTINUE READING