Identification of small molecule activators of cryptochrome.


Impairment of the circadian clock has been associated with numerous disorders, including metabolic disease. Although small molecules that modulate clock function might offer therapeutic approaches to such diseases, only a few compounds have been identified that selectively target core clock proteins. From an unbiased cell-based circadian phenotypic screen… (More)
DOI: 10.1126/science.1223710


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@article{Hirota2012IdentificationOS, title={Identification of small molecule activators of cryptochrome.}, author={Tsuyoshi Hirota and Jae Wook Lee and Peter C St John and Mariko Sawa and Keiko Iwaisako and Takako Noguchi and Pagkapol Y. Pongsawakul and Tim Sonntag and David K. Welsh and D. Brenner and Francis J. Doyle and Peter G. Schultz and Steve A Kay}, journal={Science}, year={2012}, volume={337 6098}, pages={1094-7} }