Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels.

@article{Zifarelli2010IdentificationOS,
  title={Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels.},
  author={Giovanni Zifarelli and Antonella Liantonio and Antonella Gradogna and Alessandra Picollo and Gianluca Gramegna and Michela De Bellis and Anna Rosa Murgia and Elena Babini and Diana Conte Camerino and Michael Pusch},
  journal={British journal of pharmacology},
  year={2010},
  volume={160 7},
  pages={1652-61}
}
BACKGROUND AND PURPOSE ClC-K kidney Cl(-) channels are important for renal and inner ear transepithelial Cl(-) transport, and are potentially interesting pharmacological targets. They are modulated by niflumic acid (NFA), a non-steroidal anti-inflammatory drug, in a biphasic way: NFA activates ClC-Ka at low concentrations, but blocks the channel above approximately 1 mM. We attempted to identify the amino acids involved in the activation of ClC-Ka by NFA. EXPERIMENTAL APPROACH We used site… CONTINUE READING
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