Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers.

@article{Bharaj2002IdentificationOS,
  title={Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers.},
  author={Bhupinder B Bharaj and L. Luo and Klaus Jung and Carsten Stephan and Eleftherios P Diamandis},
  journal={The Prostate},
  year={2002},
  volume={51 1},
  pages={35-41}
}
BACKGROUND The KLK10 gene (also known as the normal epithelial cell-specific 1 gene) is a member of the expanded human kallikrein gene family. Recently, it has been reported that KLK10 is a tumor suppressor gene and that its expression is downregulated in various forms of cancer and cancer cell lines. KLK10 is also upregulated in ovarian cancer. We thus hypothesized that the KLK10 gene may be a target for mutations in various cancers. METHODS We sequenced the five coding exons of the KLK10… CONTINUE READING

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