Identification of signal sequence binding proteins integrated into the rough endoplasmic reticulum membrane.

@article{Robinson1987IdentificationOS,
  title={Identification of signal sequence binding proteins integrated into the rough endoplasmic reticulum membrane.},
  author={Anna V. Robinson and Mustak A. Kaderbhai and B. Austen},
  journal={The Biochemical journal},
  year={1987},
  volume={242 3},
  pages={767-77}
}
An azidophenacyl derivative of a chemically synthesized consensus signal peptide has been prepared. The peptide, when photoactivated in the presence of rough or high-salt-stripped microsomes from pancreas, leads to inhibition of their activity in cotranslational processing of secretory pre-proteins translated from their mRNA in vitro. The peptide binds specifically with high affinity to components in the microsomal membranes from pancreas and liver, and photoreaction of a radioactive form of… CONTINUE READING
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