Identification of shikimate kinase inhibitors among anti-Mycobacterium tuberculosis compounds by LC-MS.

@article{Simithy2014IdentificationOS,
  title={Identification of shikimate kinase inhibitors among anti-Mycobacterium tuberculosis compounds by LC-MS.},
  author={Johayra Simithy and Nathaniel Reeve and Judith Varady Hobrath and Robert C. Reynolds and Angela I Calder{\'o}n},
  journal={Tuberculosis},
  year={2014},
  volume={94 2},
  pages={152-8}
}
Increasing drug resistance has challenged the control and treatment of tuberculosis, sparking recent interest in finding new antitubercular agents with different chemical scaffolds and mechanisms of action. Mycobacterium tuberculosis shikimate kinase (MtSK), an enzyme present in the shikimate pathway in bacteria, is essential for the survival of the tubercle bacillus, representing an ideal target for therapeutic intervention given its absence in mammals. In this study, a small library of 404… CONTINUE READING