Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

  title={Identification of seven new prostate cancer susceptibility loci through a genome-wide association study},
  author={Rosalind A. Eeles and Zsofia Kote-Jarai and Ali Amin Al Olama and Graham G. Giles and Michelle Guy and Gianluca Severi and Kenneth Ross Muir and John L. Hopper and Brian E. Henderson and Christopher A. Haiman and Johanna Schleutker and Freddie Hamdy and David E. Neal and Jenny L Donovan and Janet L. Stanford and Elaine A Ostrander and Sue Ann Ingles and Esther M John and Stephen N. Thibodeau and Daniel J. Schaid and Jong Y. Park and Amanda B Spurdle and Judith Ann Clements and Joanne L Dickinson and Christiane Maier and Walther Vogel and Thilo D{\"o}rk and Timothy R. Rebbeck and Kathleen A Cooney and Lisa A. Cannon-Albright and Pierre O Chappuis and Pierre Hutter and Maurice P. A. Zeegers and Radka Kaneva and Hongwei Zhang and Yong-Jie Lu and William D Foulkes and Dallas English and Daniel A. Leongamornlert and Malgorzata Tymrakiewicz and Jonathan Morrison and Audrey T Ardern-Jones and Amanda L Hall and Lynne T O'Brien and Rosemary A. Wilkinson and Edward J. Saunders and Elizabeth C. Page and Emma J. Sawyer and Stephen M Edwards and David Paul Dearnaley and Alan H. Horwich and Robert A Huddart and Vincent Khoo and Christopher C. Parker and Nicholas J Van As and Christopher R J Woodhouse and Alan Thompson and Tim J Christmas and Chris Ogden and Colin S Cooper and Melissa C. Southey and Artitaya Lophatananon and Jo-Fen Liu and Laurence N. Kolonel and Loic Le Marchand and Tiina A Wahlfors and Teuvo L. J. Tammela and Anssi Auvinen and Sarah Jayne Lewis and Angela Cox and L M FitzGerald and Joseph S Koopmeiners and Danielle M. Karyadi and Erika M. Kwon and Mariana C. Stern and R. Prieto Corral and Amit D. Joshi and Ahva Shahabi and Shannon K. McDonnell and Thomas A. Sellers and Julio M. Pow-Sang and Suzanne K Chambers and Joanne Aitken and Robert Frank A Gardiner and Jyotsna Batra and Mary Anne Kedda and Felicity A. Lose and Andrea M. Polanowski and Briony Patterson and Juergen Serth and Andreas Meyer and Manuel Luedeke and Klara Stefflova and Anna M. Ray and Ethan M. Lange and Jim Farnham and Humera S Khan and Chavdar Slavov and Atanaska Velichkova Mitkova and Guangwen Cao and Douglas F. Easton},
  journal={Nature Genetics},
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage… CONTINUE READING
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