Identification of sequences responsible for transcriptional regulation of the strongly expressed methanol oxidase-encoding gene in Hansenula polymorpha.

@article{Goedecke1994IdentificationOS,
  title={Identification of sequences responsible for transcriptional regulation of the strongly expressed methanol oxidase-encoding gene in Hansenula polymorpha.},
  author={Stefanie Goedecke and Markus Eckart and Zbigniew A. Janowicz and Cornelis P. Hollenberg},
  journal={Gene},
  year={1994},
  volume={139 1},
  pages={35-42}
}
The methylotrophic yeasts have been the subject of intensive studies, because of their highly regulated methanol metabolism and the biogenesis of peroxisomes. We investigated the 5' regulatory region of the MOX gene from the yeast, Hansenula polymorpha, encoding the peroxisomal methanol oxidase, the key enzyme of methanol metabolism. This tightly regulated yeast promoter of approximately 1.5 kb is unusually large, and also of remarkable strength under inducing conditions, belonging to the… CONTINUE READING

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