Identification of sequence motifs in oligonucleotides whose presence is correlated with antisense activity.

@article{Matveeva2000IdentificationOS,
  title={Identification of sequence motifs in oligonucleotides whose presence is correlated with antisense activity.},
  author={Olga V. Matveeva and Alexander D. Tsodikov and Michael Giddings and Susan M. Freier and Jacqueline R. Wyatt and Alexey N. Spiridonov and Svetlana A. Shabalina and Raymond F. Gesteland and John F. Atkins},
  journal={Nucleic acids research},
  year={2000},
  volume={28 15},
  pages={2862-5}
}
Design of antisense oligonucleotides targeting any mRNA can be much more efficient when several activity-enhancing motifs are included and activity-decreasing motifs are avoided. This conclusion was made after statistical analysis of data collected from >1000 experiments with phosphorothioate-modified oligonucleotides. Highly significant positive correlation between the presence of motifs CCAC, TCCC, ACTC, GCCA and CTCT in the oligonucleotide and its antisense efficiency was demonstrated. In… CONTINUE READING

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Antisense Nucleic Acid

  • T. F. Smetsers, J. B. Boezeman, E. J. Mensink
  • Drug Dev.,
  • 1996

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