Identification of sequence changes responsible for the attenuation of highly virulent infectious bursal disease virus.

@article{Yamaguchi1996IdentificationOS,
  title={Identification of sequence changes responsible for the attenuation of highly virulent infectious bursal disease virus.},
  author={Tsuyoshi Yamaguchi and Makoto Ogawa and Yasuo Inoshima and Masahiro Miyoshi and Hideto Fukushi and Kanji Hirai},
  journal={Virology},
  year={1996},
  volume={223 1},
  pages={219-23}
}
The genetic changes responsible for the attenuation of infectious bursal disease virus (IBDV) have not been defined at the molecular level, although passage of the virus in cell culture results in the loss of virulence. To understand the molecular basis of IBDV virulence and attenuation, the IBDV genome segment encoding the precursor polyprotein (NH2-VP2-VP4-VP3-COOH) of a cell culture-adapted OKYMT strain derived from highly virulent OKYM was cloned as cDNA, and the nucleotide sequence was… CONTINUE READING
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