Identification of selective cyclin-dependent kinase 2 inhibitor from the library of pyrrolone-fused benzosuberene compounds: an in silico exploration.

@article{Singh2021IdentificationOS,
  title={Identification of selective cyclin-dependent kinase 2 inhibitor from the library of pyrrolone-fused benzosuberene compounds: an in silico exploration.},
  author={Rahul Singh and Vijay Kumar Bhardwaj and Jatin Sharma and Pralay Das and Rituraj Purohit},
  journal={Journal of biomolecular structure \& dynamics},
  year={2021},
  pages={
          1-9
        }
}
The over-expression of cyclin-dependent kinase 2 is related to multiple cancers, which has led them to be a widely researched topic for nearly two decades. The prime focus of the present research is to design new potent and specific inhibitors against CDK2 to suppress cancer cell proliferation. In this study, we have chosen Flavopiridol, SU9516, and CVT-313 as standard inhibitors to compare with in-house synthesized pyrrolone-fused benzosuberene (PBS) compounds. We scrutinized Ligand2 as a… 
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