Identification of rodent carcinogens and noncarcinogens using genetic toxicity tests: premises, promises, and performance.

@article{Zeiger1998IdentificationOR,
  title={Identification of rodent carcinogens and noncarcinogens using genetic toxicity tests: premises, promises, and performance.},
  author={Errol Zeiger},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={1998},
  volume={28 2},
  pages={85-95}
}
  • Errol Zeiger
  • Published 1998 in Regulatory toxicology and pharmacology : RTP
The basic premises that guide genetic toxicity testing for identifying carcinogens and to support administrative and regulatory decisions are: the Salmonella mutagenicity test is a necessary component of testing schemes; a chromosome aberration test is needed in addition to a gene mutation test; a mammalian cell mutagenicity test is needed in addition to the Salmonella test; in vivo tests are needed to confirm the results of in vitro tests; and test batteries are more predictive than the… CONTINUE READING
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