Identification of risk factors for exertional heat illness: a brief commentary on genetic testing.
@article{Muldoon2007IdentificationOR,
title={Identification of risk factors for exertional heat illness: a brief commentary on genetic testing.},
author={Sheila M. Muldoon and Rolf Bunger and Patricia A. Deuster and Nyamkhishig Sambuughin},
journal={Journal of sport rehabilitation},
year={2007},
volume={16 3},
pages={
222-6
}
}OBJECTIVE
This commentary discusses known links between Exertional Heat Illness (EHI), Malignant Hyperthermia (MH), and other hereditary diseases of muscle. Genetic and functional testing is also evaluated as measures of fitness to return to duty/play.
DATA SOURCES
Reviews and research articles from Sports Medicine, Applied Physiology, and Anesthesiology.
DATA EXTRACTION
Detailed comparisons of existing literature regarding clinical cases of EHI and MH and the potential utility of genetic…Â
7 Citations
Heat illness in military populations: asking the right questions for research
- Environmental ScienceJournal of the Royal Army Medical Corps
- 2014
Research questions in support of the health of military populations who may experience exertional heat stress are set out and the mechanisms by which excess body heat arises and is dissipated are outlined and the significance of core temperature measurement during exercise is discussed.
Exertional Heat Illness, Exertional Rhabdomyolysis, and Malignant Hyperthermia: Is There a Link?
- MedicineCurrent sports medicine reports
- 2008
Recommendations for treatment and recovery include cooling and administration of dantrolene for MH, cooling and aggressive fluid administration for EHI, and physical rest and aggressive intravenous fluid administrationfor ER.
On-Site Treatment of Exertional Heat Stroke
- MedicineThe American journal of sports medicine
- 2015
On-site treatment of athletes who develop exertional heat stroke appears to be both safe and effective, and may decrease the local burden of critically ill patients to emergency departments during large athletic events.
Unusual heat stroke caused by herbal therapy with traditional Chinese medicine.
- MedicineNeurosciences
- 2014
A case of heat stroke that was associated with herbal therapy with TCM is reported, highlighting the importance of paying more attention to unidentified folk prescriptions in the use of TCM.
Eleven days of moderate exercise and heat exposure induces acclimation without significant HSP70 and apoptosis responses of lymphocytes in college-aged males
- BiologyCell Stress and Chaperones
- 2011
It is concluded that the protocol successfully induced physiological acclimation without induction of cellular heat shock responses in lymphocytes and that added mild sleep loss is not sufficient to induce a heat shock response.
Military nephrology—what a civilian doctor should know
- MedicineNDT plus
- 2011
The primary objective of the Defence Medical Services is the maintenance of operational capability of military personnel, which includes exclusion of nephrological diseases that might reduce renal reserve to a critical level under field conditions.
Riscos associados à prática de esforço em condições de calor extremas
- Physics
- 2011
O ambiente termico e um factor que condiciona toda a actividade humana, em qualquer ponto do planeta. Os ambientes termicos quentes tem efeitos nefastos nas populacoes de todas as idades, estando na…
References
SHOWING 1-10 OF 13 REFERENCES
Collapse from exertional heat illness: implications and subsequent decisions.
- BiologyMilitary medicine
- 2003
There is a need to bypass considerations of the etiology of EHI and to identify the vulnerable and handicapped soldier by exposure after an interval of time to one or more exercise tolerance tests.
Is there a link between malignant hyperthermia and exertional heat illness?
- MedicineBritish Journal of Sports Medicine
- 2007
There is a link between malignant hyperthermia and exertional heat illness and there are, however, sporadic cases that occur in individuals, with no obvious predisposing factors, exercising in unremarkable weather conditions.
A Noninvasive Investigation of Muscle Energetics Supports Similarities Between Exertional Heat Stroke and Malignant Hyperthermia
- MedicineAnesthesia and analgesia
- 2001
It is demonstrated that muscle energetics are abnormal in subjects who have experienced EHS and a possible link between MH and EH is suggested, although all EHS cannot be considered as MH.
Malignant hyperthermia associated with exercise-induced rhabdomyolysis or congenital abnormalities and a novel RYR1 mutation in New Zealand and Australian pedigrees.
- Medicine, BiologyBritish journal of anaesthesia
- 2002
DNA sequence analysis of each kindred revealed the presence of a common novel mutation that results in an arginine401-cysteine substitution in the skeletal muscle ryanodine receptor gene (RYR1), providing confirmation that the MH/central core disease region 1 of RYR1 is a mutation hot spot.
Assessment of heat tolerance for post exertional heat stroke individuals.
- MedicineMedical science monitor : international medical journal of experimental and clinical research
- 2004
It was concluded that tolerance to heat must be tested during heat stress and the test duration cannot be shorter than 120 min and the comfort tolerance test was found as irrelevant for heat intolerance assessment.
Blood lactate threshold and type II fibre predominance in patients with exertional heatstroke.
- MedicineJournal of neurology, neurosurgery, and psychiatry
- 1997
Patients with type II fibre predominance are more susceptible to exertional heatstroke and tend to have a higher blood lactate concentration and a shorter time to reachBlood lactate threshold under a treadmill load test.
Rhabdomyolysis following Severe Physical Exercise in a Patient with Predisposition to Malignant Hyperthermia
- MedicineAnaesthesia and intensive care
- 1998
The in vitro contracture test is the only method used to determine susceptibility to malignant hyperthermia and should be performed when the diagnosis is suggested on clinical grounds.
Malignant Hyperthermia Genetic Testing in North America Working Group Meeting.
- BiologyAnesthesiology
- 2004
Am J Anesthesiol. October
- Am J Anesthesiol. October
- 2001