Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.

  title={Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.},
  author={S. A. Oliveira and Y. Li and Maher A. Noureddine and S. Zuchner and Xuejun Qin and M. Pericak-Vance and J. Vance},
  journal={American journal of human genetics},
  volume={77 2},
  • S. A. Oliveira, Y. Li, +4 authors J. Vance
  • Published 2005
  • Biology, Medicine
  • American journal of human genetics
  • We previously reported a linkage region on chromosome 1p (LOD = 3.41) for genes controlling age at onset (AAO) in Parkinson disease (PD). This region overlaps with the previously reported PARK10 locus. To identify the gene(s) associated with AAO and risk of PD in this region, we first applied a genomic convergence approach that combined gene expression and linkage data. No significant results were found. Second, we performed association mapping across a 19.2-Mb region centered under the AAO… CONTINUE READING
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