Identification of renin in resident alveolar macrophages and monocytes: HPLC and immunohistochemical study.

@article{Dezs1988IdentificationOR,
  title={Identification of renin in resident alveolar macrophages and monocytes: HPLC and immunohistochemical study.},
  author={Bal{\'a}zs Dezs{\"o} and Allan Holm Nielsen and Karl. Poulsen},
  journal={Journal of cell science},
  year={1988},
  volume={91 ( Pt 1)},
  pages={155-9}
}
Normal, unstimulated alveolar macrophages (AM) and monocytes (Mo) from both mice and rats have been shown to exhibit an angiotensin-I-forming enzyme. This protease has a similar or identical molecular weight to plasma renin as judged by HPLC analysis. In addition, the enzyme activity could be almost completely inhibited by a specific antibody to pure mouse submaxillary gland renin. This indicates that the angiotensin-I-generating protease in AM and Mo is identical to true renin. These results… CONTINUE READING
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