Identification of renal natriuretic peptide receptor subpopulations by use of the non-peptide antagonist, HS-142-1.

Abstract

1. The renal actions of natriuretic peptides are dictated by the distribution of guanylyl cyclase-linked (NPRA and NPRB) and non-guanylyl cyclase-linked (NPRC) receptors. Natriuretic peptide receptors have previously been distinguished on the basis of their differential affinity for peptide fragments and analogues; however, most of the available ligands are… (More)

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