Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension

  title={Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension},
  author={Michal Pravenec and Paul C Churchill and Monique C Churchill and Ondřej Viklick{\'y} and Ludmila Kazdov{\'a} and Timothy J. Aitman and Enrico Petretto and Norbert Hubner and Caroline A. Wallace and Heike Zimdahl and V{\'a}clav Z{\'i}dek and Vladim{\'i}r Landa and Joseph B. Dunbar and Anil K. Bidani and Karen Griffin and Nathan Qi and Martina Maxov{\'a} and Vladim{\'i}r Křen and Petr Mlejnek and Jiaming Wang and Theodore W. Kurtz},
  journal={Nature Genetics},
To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty… CONTINUE READING