Identification of regulatory targets of tissue-specific transcription factors: application to retina-specific gene regulation

@article{Qian2005IdentificationOR,
  title={Identification of regulatory targets of tissue-specific transcription factors: application to retina-specific gene regulation},
  author={Jiang Qian and Noriko Esumi and Yangjian Chen and Qingliang Wang and Itay Chowers and Donald J. Zack},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={3479 - 3491}
}
Identification of tissue-specific gene regulatory networks can yield insights into the molecular basis of a tissue's development, function and pathology. Here, we present a computational approach designed to identify potential regulatory target genes of photoreceptor cell-specific transcription factors (TFs). The approach is based on the hypothesis that genes related to the retina in terms of expression, disease and/or function are more likely to be the targets of retina-specific TFs than other… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

The role of cis-regulatory elements in the design of gene therapy vectors for inherited blindness.

Expert opinion on biological therapy • 2008
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 77 references

The rod photoreceptor-specific nuclear receptor Nr2e3 represses transcription of multiple cone-specific genes.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2005
View 1 Excerpt

[Finishing the euchromatic sequence of the human genome].

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme • 2005

Similar Papers

Loading similar papers…