Identification of regulatory modules by co-clustering latent variable models: stem cell differentiation

Abstract

MOTIVATION An important issue in stem cell biology is to understand how to direct differentiation towards a specific cell type. To elucidate the mechanism, previous studies have focused on identifying the responsible gene regulators, which have, however, failed to provide a systemic view of regulatory modules. To obtain a unified description of the… (More)
DOI: 10.1093/bioinformatics/btl343

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