Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas.

@article{Everhard2009IdentificationOR,
  title={Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas.},
  author={Sibille Everhard and J{\"o}rg Tost and Hafida El abdalaoui and Emmanuelle Crini{\`e}re and Florence Busato and Yannick Marie and Ivo G Gut and Marc Sanson and Karima Mokhtari and Florence Laigle-Donadey and Kh{\^e} Hoang-Xuan and Jean-Yves Delattre and J. Thillet},
  journal={Neuro-oncology},
  year={2009},
  volume={11 4},
  pages={348-56}
}
The O(6)-methylguanine-DNA methyltransferase gene (MGMT) is methylated in several cancers, including gliomas. However, the functional role of cysteine-phosphate-guanine (CpG) island (CGI) methylation in MGMT silencing is still controversial. The aim of this study was to investigate whether MGMT CGI methylation correlates inversely with RNA expression of… CONTINUE READING