Identification of rcnA (yohM), a nickel and cobalt resistance gene in Escherichia coli.

@article{Rodrigue2005IdentificationOR,
  title={Identification of rcnA (yohM), a nickel and cobalt resistance gene in Escherichia coli.},
  author={Agn{\`e}s Rodrigue and G{\'e}raldine Effantin and Marie-Andr{\'e}e Mandrand-Berthelot},
  journal={Journal of bacteriology},
  year={2005},
  volume={187 8},
  pages={2912-6}
}
We report here on the isolation and primary characterization of the yohM gene of Escherichia coli. We show that yohM encodes a membrane-bound polypeptide conferring increased nickel and cobalt resistance in E. coli. yohM was specifically induced by nickel or cobalt but not by cadmium, zinc, or copper. Mutation of yohM increased the accumulation of nickel inside the cell, whereas cells harboring yohM in multicopy displayed reduced intracellular nickel content. Our data support the hypothesis… CONTINUE READING

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