Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor.

@article{Seetharam1997IdentificationOR,
  title={Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor.},
  author={Bellur Seetharam and Erik Ils\o Christensen and S\oren K Moestrup and Timothy G Hammond and Pierre J. Verroust},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={99 10},
  pages={2317-22}
}
Previous studies in the rat have shown that antibodies to gp280, a protein > 200 kD and closely associated with the early endocytic system can induce fetal malformations. Although gp280 is thought to act as a receptor, its ligand(s) is not known. In the current study, we report that purified gp280 from rat kidney, like the intrinsic factor-Cobalamin receptor (IFCR), binds to the intrinsic factor-cobalamin (IFCbl) complex with an association constant of 0.3 x 10(9) M-1 and mediates its… CONTINUE READING