Identification of rat susceptibility loci for adjuvant-oil-induced arthritis.

  title={Identification of rat susceptibility loci for adjuvant-oil-induced arthritis.},
  author={J C Lorentzen and Anna Glaser and Lena Jacobsson and Joakim Galli and H Fakhrai-rad and Lars Klareskog and Holger Luthman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 11},
One intradermal injection of incomplete Freund's adjuvant-oil induces a T cell-mediated inflammatory joint disease in DA rats. Susceptibility genes for oil-induced arthritis (OIA) are located both within and outside the major histocompatibility complex (MHC, Oia1). We have searched for disease-linked non-MHC loci in an F2 intercross between DA rats and MHC-identical but arthritis-resistant LEW.1AV1 rats. A genome-wide scan with microsatellite markers revealed two major chromosome regions that… CONTINUE READING
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