Identification of rare nonsynonymous variants in SYNE1/CPG2 in bipolar affective disorder.

@article{Sharp2017IdentificationOR,
  title={Identification of rare nonsynonymous variants in SYNE1/CPG2 in bipolar affective disorder.},
  author={Sally Isabel Sharp and Jenny S. Lange and Radhika Kandaswamy and Mazen Daher and Adebayo Anjorin and Nicholas J Bass and Andrew McQuillin},
  journal={Psychiatric genetics},
  year={2017},
  volume={27 3},
  pages={
          81-88
        }
}
BACKGROUND Bipolar affective disorder (BPD) is a severe mood disorder with a prevalence of ∼1.5% in the population. The pathogenesis of BPD is poorly understood; however, a strong heritable component has been identified. Previous genome-wide association studies have indicated a region on 6q25, coding for the SYNE1 gene, which increases disease susceptibility. SYNE1 encodes the synaptic nuclear envelope protein-1, nesprin-1. A brain-specific splice variant of SYNE1, CPG2 encoding candidate… CONTINUE READING
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