Identification of rare alleles and their carriers using compressed se(que)nsing

@inproceedings{Shental2010IdentificationOR,
  title={Identification of rare alleles and their carriers using compressed se(que)nsing},
  author={Noam Shental and Amnon Amirand and Or Zuk},
  booktitle={Nucleic acids research},
  year={2010}
}
Identification of rare variants by resequencing is important both for detecting novel variations and for screening individuals for known disease alleles. New technologies enable low-cost resequencing of target regions, although it is still prohibitive to test more than a few individuals. We propose a novel pooling design that enables the recovery of novel or known rare alleles and their carriers in groups of individuals. The method is based on a Compressed Sensing (CS) approach, which is… CONTINUE READING
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