Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.

@article{Xia2011IdentificationOQ,
  title={Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.},
  author={Menghang Xia and Sampada Shahane and Ruili Huang and Steven A Titus and Enoch Shum and Yong Zhao and Noel Southall and Wei Zheng and Kristine L. Witt and Raymond Richard Tice and Christopher P. Austin},
  journal={Toxicology and applied pharmacology},
  year={2011},
  volume={252 3},
  pages={250-8}
}
The human ether-a-go-go-related gene (hERG) channel, a member of a family of voltage-gated potassium (K(+)) channels, plays a critical role in the repolarization of the cardiac action potential. The reduction of hERG channel activity as a result of adverse drug effects or genetic mutations may cause QT interval prolongation and potentially leads to acquired… CONTINUE READING