Identification of putative gene based markers of renal toxicity.

@article{Amin2004IdentificationOP,
  title={Identification of putative gene based markers of renal toxicity.},
  author={Rupesh P. Amin and Alison E.M. Vickers and Frank D Sistare and Karol L. Thompson and Richard Joseph Roman and Michael T. Lawton and Jeffrey Alan Kramer and Hisham Hamadeh and Jennifer K. Collins and Sherry F. Grissom and Lee Bennett and Compton J. Tucker and Stacie Lynn. Wild and Clive N. Kind and Victor Oreffo and John W. Davis and Sandra W. Curtiss and Jorge M. Naciff and Michael Doucette Cunningham and Raymond Tennant and James V. Stevens and Bruce Car and Timothy Allyn Bertram and Cynthia A. Afshari},
  journal={Environmental Health Perspectives},
  year={2004},
  volume={112},
  pages={465 - 479}
}
This study, designed and conducted as part of the International Life Sciences Institute working group on the Application of Genomics and Proteomics, examined the changes in the expression profile of genes associated with the administration of three different nephrotoxicants--cisplatin, gentamicin, and puromycin--to assess the usefulness of microarrays in the understanding of mechanism(s) of nephrotoxicity. Male Sprague-Dawley rats were treated with daily doses of puromycin (5-20 mg/kg/day for… CONTINUE READING

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