Identification of putative dental epithelial stem cells in a lizard with life-long tooth replacement.

@article{Handrigan2010IdentificationOP,
  title={Identification of putative dental epithelial stem cells in a lizard with life-long tooth replacement.},
  author={Gregory Ryan Handrigan and Kelvin Jia-Mien Leung and Joy M Richman},
  journal={Development},
  year={2010},
  volume={137 21},
  pages={3545-9}
}
Most dentate vertebrates, including humans, replace their teeth and yet the process is poorly understood. Here, we investigate whether dental epithelial stem cells exist in a polyphyodont species, the leopard gecko (Eublepharis macularius). Since the gecko dental epithelium lacks a histologically distinct site for stem cells analogous to the mammalian hair follicle bulge, we performed a pulse-chase experiment on juvenile geckos to identify label-retaining cells (LRCs). We detected LRCs… CONTINUE READING
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