Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics.

@article{Feder2012IdentificationOP,
  title={Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics.},
  author={Daniel Feder and Waleed M. Hussein and Daniel J Clayton and Meng-Wei Kan and Gerhard Schenk and Ross P. McGeary and Luke W. Guddat},
  journal={Chemical biology & drug design},
  year={2012},
  volume={80 5},
  pages={665-74}
}
Purple acid phosphatases are metalloenzymes found in animals, plants and fungi. They possess a binuclear metal centre to catalyse the hydrolysis of phosphate esters and anhydrides under acidic conditions. In humans, elevated purple acid phosphatases levels in sera are correlated with the progression of osteoporosis and metabolic bone malignancies, making this enzyme a target for the development of new chemotherapeutics to treat bone-related illnesses. To date, little progress has been achieved… CONTINUE READING
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