Identification of prothymosin-α1, the necrosis–apoptosis switch molecule in cortical neuronal cultures

  title={Identification of prothymosin-α1, the necrosis–apoptosis switch molecule in cortical neuronal cultures},
  author={Hiroshi Ueda and Ryousuke Fujita and Akira Yoshida and Hayato Matsunaga and Mutsumi Ueda},
  journal={The Journal of Cell Biology},
  pages={853 - 862}
We initially identified a nuclear protein, prothymosin-alpha1 (ProTalpha), as a key protein inhibiting necrosis by subjecting conditioned media from serum-free cultures of cortical neurons to a few chromatography steps. ProTalpha inhibited necrosis of cultured neurons by preventing rapid loss of cellular adenosine triphosphate levels by reversing the decreased membrane localization of glucose transporters but caused apoptosis through up-regulation of proapoptotic Bcl(2)-family proteins. The… CONTINUE READING


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