Identification of prothymosin-α1, the necrosis–apoptosis switch molecule in cortical neuronal cultures

@article{Ueda2007IdentificationOP,
  title={Identification of prothymosin-α1, the necrosis–apoptosis switch molecule in cortical neuronal cultures},
  author={Hiroshi Ueda and Ryousuke Fujita and Akira Yoshida and Hayato Matsunaga and Mutsumi Ueda},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={176},
  pages={853 - 862}
}
We initially identified a nuclear protein, prothymosin-alpha1 (ProTalpha), as a key protein inhibiting necrosis by subjecting conditioned media from serum-free cultures of cortical neurons to a few chromatography steps. ProTalpha inhibited necrosis of cultured neurons by preventing rapid loss of cellular adenosine triphosphate levels by reversing the decreased membrane localization of glucose transporters but caused apoptosis through up-regulation of proapoptotic Bcl(2)-family proteins. The… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Large G protein α-subunit XLαs limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo.

Proceedings of the National Academy of Sciences of the United States of America • 2017

T Lymphocyte-Specific Activation of Nrf2 Protects from AKI.

Journal of the American Society of Nephrology : JASN • 2015

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Selective interaction between parathymosin and histone H1.

European journal of biochemistry • 1996
View 1 Excerpt
Highly Influenced

Role of protein kinase B in insulin - regulated glucose uptake

B. C. White, J. M. Sullivan, +5 authors G. S. Krause
Biochem . Soc . Trans . • 2005

Bax-inhibiting peptide derived from mouse and rat Ku70.

Biochemical and biophysical research communications • 2004

Similar Papers

Loading similar papers…