Identification of proteins with high affinity for refolded and native PrPC.

@article{Petrakis2006IdentificationOP,
  title={Identification of proteins with high affinity for refolded and native PrPC.},
  author={Spyros Petrakis and Theodoros Sklaviadis},
  journal={Proteomics},
  year={2006},
  volume={6 24},
  pages={6476-84}
}
PrPC, the cellular prion protein, is widely expressed in most tissues, including brain, muscle and the gastrointestinal tract, but its physiological role remains unclear. During propagation of transmissible spongiform encephalopathies (TSEs), prion protein is converted to the pathological isoform, PrPSc, in a process believed to be mediated by as-yet-unknown host factors. The identification of proteins associated with PrP may provide information about the biology of prions and the pathogenesis… CONTINUE READING

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