Identification of proteins associated with transcription factors HOXA9 and E2A-PBX1 by tandem affinity purification

Abstract

Chimeric transcription factor E2A-PBX1 induces the development of acute lymphoblastic B-cell leukemia in children. Using a transgenic mouse model, we previously demonstrated that homeobox (HOX) gene HOXA9 genetically interact with E2A-PBX1 gene in the development of B-cell leukemia in mice. HOXA9 itself is a potent oncogene resulting in myeloid leukemia… (More)
DOI: 10.1134/S002689331703013X

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