Identification of protein modifications using MS/MS de novo sequencing and the OpenSea alignment algorithm.

@article{Searle2005IdentificationOP,
  title={Identification of protein modifications using MS/MS de novo sequencing and the OpenSea alignment algorithm.},
  author={Brian C Searle and Surendra Dasari and Phillip A. Wilmarth and Mark Turner and A. Pratapa Reddy and Larry L. David and Srinivasa R. Nagalla},
  journal={Journal of proteome research},
  year={2005},
  volume={4 2},
  pages={546-54}
}
Algorithms that can robustly identify post-translational protein modifications from mass spectrometry data are needed for data-mining and furthering biological interpretations. In this study, we determined that a mass-based alignment algorithm (OpenSea) for de novo sequencing results could identify post-translationally modified peptides in a high-throughput environment. A complex digest of proteins from human cataractous lens, a tissue containing a high abundance of modified proteins, was… CONTINUE READING
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