Identification of protein coding regions in RNA transcripts

  title={Identification of protein coding regions in RNA transcripts},
  author={Shiyuyun Tang and Alexandre Lomsadze and Mark Yu Borodovsky},
  booktitle={Nucleic acids research},
Massive parallel sequencing of RNA transcripts by next-generation technology (RNA-Seq) generates critically important data for eukaryotic gene discovery. Gene finding in transcripts can be done by statistical (alignment-free) as well as by alignment-based methods. We describe a new tool, GeneMarkS-T, for ab initio identification of protein-coding regions in RNA transcripts. The algorithm parameters are estimated by unsupervised training which makes unnecessary manually curated preparation of… CONTINUE READING
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