Identification of protective B cell antigens of Legionella pneumophila.

  title={Identification of protective B cell antigens of Legionella pneumophila.},
  author={Stefan S. Weber and Nicole Joller and Anna Barbara K{\"u}ntzel and Roman Sp{\"o}rri and Vincent Sam Yong Tchang and Elke Scandella and Christoph P Roesli and Burkhard Ludewig and Hubert Hilbi and Annette Oxenius},
  journal={Journal of immunology},
  volume={189 2},
Abs confer protection from secondary infection with Legionella pneumophila, the causative agent of a severe form of pneumonia known as Legionnaires' disease. In this study, we demonstrate that Ab-mediated protection is effective across L. pneumophila serogroups, suggesting that Abs specific for conserved protein Ags are sufficient to mediate this protective effect. We used two independent methods to identify immunogenic L. pneumophila protein Ags, namely, the screening of a λ phage library… CONTINUE READING