Identification of prosaposin as a neurotrophic factor.

  title={Identification of prosaposin as a neurotrophic factor.},
  author={John S. O'brien and Geoffrey S. Carson and Hyoung Cheol Seo and Masao Hiraiwa and Yasuo Kishimoto},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={91 20},
Prosaposin was identified as a neurotrophic factor stimulating neurite outgrowth in murine neuroblastoma (NS20Y) cells and choline acetyltransferase (ChAT) activity in human neuroblastoma (SK-N-MC) cells. The four naturally occurring saposins, which are derived by proteolytic processing of prosaposin, were tested for activity. Saposin C was found to be… CONTINUE READING