Identification of prohibitin as a Chikungunya virus receptor protein

@article{Wintachai2012IdentificationOP,
  title={Identification of prohibitin as a Chikungunya virus receptor protein},
  author={Phitchayapak Wintachai and Nitwara Wikan and Atichat Kuadkitkan and Thitigun Jaimipuk and Sukathida Ubol and Rojjanaporn Pulmanausahakul and Prasert Auewarakul and Watchara Kasinrerk and Wenlian Weng and Mingkwan Panyasrivanit and Atchara Paemanee and Suthathip Kittisenachai and Sittiruk Roytrakul and Duncan R. Smith},
  journal={Journal of Medical Virology},
  year={2012},
  volume={84}
}
Chikungunya virus (CHIKV) has recently re‐emerged causing millions of infections in countries around the Indian Ocean. While CHIKV has a broad host cell range and productively infects a number of different cell types, macrophages have been identified as a potential viral reservoir serving to increase the duration of symptoms. To date no CHIKV interacting protein has been characterized and this study sought to identify CHIKV binding proteins expressed on target cell membranes. Two‐dimensional… 
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The CD147 Protein Complex Is Involved in Entry of Chikungunya Virus and Related Alphaviruses in Human Cells
TLDR
An affinity purification mass spectrometry coupled approach was designed that allowed the identification of factors that facilitate entry of CHIKV in human cells and showed the involvement of the CD147 protein complex in the replication cycle of related alphaviruses.
Chikungunya Virus Strains from Each Genetic Clade Bind Sulfated Glycosaminoglycans as Attachment Factors
TLDR
GAGs are the preferred glycan bound by CHIKV, enhance the understanding of the specific GAG moieties required forCHIKV binding, define strain differences in GAG engagement, and provide further evidence for a critical function of GAGs in CHikV cell attachment and infection.
Identification of chikungunya virus interacting proteins in mammalian cells
TLDR
Results suggest that chikungunya virus exploits the housekeeping molecules such as actin, HSP70 and STAT-2 to establish infection in the mammalian cells.
Assessment of flavaglines as potential chikungunya virus entry inhibitors
TLDR
All three compounds inhibited infection and reduced virus production when cells were treated before infection but not when added after infection, suggesting that further investigation of prohibitin ligands as potential Chikungunya virus entry inhibitors is warranted.
Global protein profiling studies of chikungunya virus infection identify different proteins but common biological processes
TLDR
While a broad consensus is emerging on which biological processes are altered during CHIKV infection, this consensus is poorly supported in terms of consistent identification of any key proteins mediating those biological processes.
Chikungunya Virus Interacts with Heat Shock Cognate 70 Protein to Facilitate Its Entry into Mosquito Cell Line
TLDR
HSC 70 serves as a putative Chikungunya virus (CHIKV) receptor/s on C6/36 cells that facilitate viral entry and co-IP experiments confirmed the interaction between HSC 70 and CHIKV envelope.
Early Events in Chikungunya Virus Infection—From Virus Cell Binding to Membrane Fusion
TLDR
The aim of the review is to give the reader a state-of-the-art overview on Chikungunya virus cell entry and to provide an outlook on potential new avenues in CHIKV research.
Chikungunya and Its Interaction With the Host Cell
TLDR
This review summarises the CHIKV genome organization, replication, epidemiology, clinical manifestations, and immunopathogenesis with particular emphasis on host-pathogen interactions and concludes that the virus has emerged as a true global pathogen.
The Phosphatidylserine Receptor TIM-1 Enhances Authentic Chikungunya Virus Cell Entry
TLDR
Findings indicate that, unlike Axl, TIM-1 readily promotes the productive entry of authentic CHIKV into target cells, and this work shows that point mutations in the phosphatidylserine binding site of TIM- 1 lead to reduced cell binding, entry, and infection of CHikV.
Host–pathogen interactome analysis of Chikungunya virus envelope proteins E1 and E2
TLDR
The identified interactions shed light on the possible cellular machinery that CHIKV might be employing during viral entry, trafficking, and evasion of immune system.
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