Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway.

@article{Korherr2006IdentificationOP,
  title={Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway.},
  author={Christian Korherr and Hendrik Gille and Rolf Sch{\"a}fer and Kerstin Koenig-Hoffmann and Johan Dixelius and Kristi A. Egland and Ira Pastan and Ulrich Brinkmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 11},
  pages={4240-5}
}
A genome-wide phenotype screen was used to identify factors and pathways that induce proliferation of human umbilical vein endothelial cells (HUVEC). HUVEC proliferation is a recognized marker for factors that modulate vascularization. Screening "hits" included known proangiogenic factors, such as VEGF, FGF1, and FGF2 and additional factors for which a direct association with angiogenesis was not previously described. These include the kinase TBK1 as well as Toll-like receptor adaptor molecule… CONTINUE READING
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