Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.

@article{Lee2011IdentificationOP,
  title={Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.},
  author={Julie M. Lee and L. Song and G. Terracina and Thomas A. Bara and H. Josien and T. Asberom and T. Sasikumar and D. Burnett and J. Clader and E. Parker and L. Zhang},
  journal={Biochemistry},
  year={2011},
  volume={50 22},
  pages={
          4973-80
        }
}
  • Julie M. Lee, L. Song, +8 authors L. Zhang
  • Published 2011
  • Biology, Medicine
  • Biochemistry
  • Accumulation of the β-amyloid (Aβ) peptides is one of the major pathologic hallmarks in the brains of Alzheimer's disease (AD) patients. Aβ is generated by sequential proteolytic cleavage of the amyloid precursor protein (APP) catalyzed by β- and γ-secretases. Inhibition of Aβ production by γ-secretase inhibitors (GSIs) is thus being pursued as a target for treatment of AD. In addition to processing APP, γ-secretase also catalyzes proteolytic cleavage of other transmembrane substrates, with the… CONTINUE READING
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