Identification of preferred carbohydrate binding modes in xenoreactive antibodies by combining conformational filters and binding site maps.

@article{Agostino2010IdentificationOP,
  title={Identification of preferred carbohydrate binding modes in xenoreactive antibodies by combining conformational filters and binding site maps.},
  author={Mark Agostino and Mauro Sergio Sandrin and Philip E. Thompson and Elizabeth Yuriev and Paul A. Ramsland},
  journal={Glycobiology},
  year={2010},
  volume={20 6},
  pages={
          724-35
        }
}
Carbohydrates are notoriously flexible molecules. However, they have an important role in many biochemical processes as specific ligands. Understanding how carbohydrates are recognized by other biological macromolecules (usually proteins) is therefore of considerable scientific value. Interfering with carbohydrate-protein interactions is a potentially useful strategy in combating a range of disease states, as well as being of critical importance in facilitating allo- and xenotransplantation. We… CONTINUE READING

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