Identification of potential target genes of cardioprotection against ischemia-reperfusion injury by express sequence tags analysis in rat hearts.

@article{Kim2012IdentificationOP,
  title={Identification of potential target genes of cardioprotection against ischemia-reperfusion injury by express sequence tags analysis in rat hearts.},
  author={Hyoung Kyu Kim and Se Won Kang and Seung Hun Jeong and Nari Kim and Jae Hong Ko and Hyoweon Bang and Won Sun Park and Tae-Hoon Choi and Young-Ran Ha and Yong Seok Lee and Jae Boum Youm and Kyung Soo Ko and Byoung Doo Rhee and Jin Han},
  journal={Journal of cardiology},
  year={2012},
  volume={60 2},
  pages={98-110}
}
BACKGROUND Ischemic preconditioning (IPC) is a powerful mechanism for limiting myocardial infarction during or after ischemia-reperfusion (IR) injury. However, effective target genes and proteins for IPC are unknown. We characterized global changes in gene expression in the heart during IR, and identified effective target genes for IPC. METHODS Hearts were isolated from Sprague-Dawley rats under control, IR, and IPC conditions. We generated expressed-sequence-tags (ESTs) for each group and… CONTINUE READING