Identification of potential breast cancer markers in nipple discharge by protein profile analysis using two‐dimensional nano‐liquid chromatography/nanoelectrospray ionization‐mass spectrometry

@article{Kurono2016IdentificationOP,
  title={Identification of potential breast cancer markers in nipple discharge by protein profile analysis using two‐dimensional nano‐liquid chromatography/nanoelectrospray ionization‐mass spectrometry},
  author={S. Kurono and Yuka Kaneko and N. Matsuura and H. Oishi and S. Noguchi and Seung Jin Kim and Y. Tamaki and T. Aikawa and Y. Kotsuma and H. Inaji and Shuji Matsuura},
  journal={PROTEOMICS – Clinical Applications},
  year={2016},
  volume={10}
}
This research aimed to establish a diagnostic technique for breast cancer using nipple discharge (ND), with the objective of preventive diagnosis. ND has been proposed as a source of secreted proteomes that reflect early pathological changes in the ductal‐lobular epithelial microenvironment, and could thus provide breast‐specific cancer biomarkers that could be accessed noninvasively as a new clinical diagnostic technique. 
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