Identification of potential biomarkers of gold nanoparticle toxicity in rat brains

@inproceedings{Siddiqi2012IdentificationOP,
  title={Identification of potential biomarkers of gold nanoparticle toxicity in rat brains},
  author={Nikhat Jamal Siddiqi and Mohamed Anwar K. Abdelhalim and Afaf El-Ansary and Abdullah Salih Alhomida and Wei-Yi Ong},
  booktitle={Journal of Neuroinflammation},
  year={2012}
}
Gold nanoparticles (AuNPs) are finding increased use in therapeutics and imaging. However, their toxic effects still remain to be elucidated. Therefore this study was undertaken to study the biochemical effects of AuNPs on rat brain and identify potential biomarkers of AuNP toxicity. Male Wister rats weighing 150–200 g were injected with 20 μg/kg body weight of 20-nm gold nanoparticles for 3 days through the intraperitoneal route. The rats were killed by carbon dioxide asphyxiation 24 h after… CONTINUE READING
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