Identification of positron emission tomography ligands for NPY Y5 receptors in the brain.

Abstract

A series of trans-3-oxospiro[(aza)isobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide derivatives were synthesized and profiled for NPY Y5 binding affinity, brain and CSF penetrability in rats, and susceptibility to human and mouse P-glycoprotein transporters in order to develop a PET ligand. Compound 12b exhibited an acceptable profile for a PET ligand, and… (More)
DOI: 10.1016/j.bmcl.2009.07.103

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